UV-Induced Neuronal Degeneration in the Rat Cerebral Cortex

donepezile prevents morphine-induced apoptosis in rat cerebral cortex

Experimental Degeneration in the Cerebral Cortex.

Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex.

Mild traumatic brain injury (mTBI) leads to long-term cognitive and emotional difficulties and behavioral disturbances, but the diagnosis and treatment of mTBI have historically been hampered by a lack of evidence-based correlates of these clinical manifestations. Unlike moderate and severe TBI, mTBI does not show significant tissue lesions or cavities in the cortex. Moreover, neuroimaging by m...

Effect of paraoxon on the synaptosomal GABA uptake in rat hippocampus and cerebral cortex

Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...

Neuronal polarization in the developing cerebral cortex

Cortical neurons consist of excitatory projection neurons and inhibitory GABAergic interneurons, whose connections construct highly organized neuronal circuits that control higher order information processing. Recent progress in live imaging has allowed us to examine how these neurons differentiate during development in vivo or in in vivo-like conditions. These analyses have revealed how the in...